Accessibility Tools
[contact-form-7 404 "Not Found"]

Orthobiologics are natural substances such as cells, tissue, blood components and growth factors that are harnessed to aid in the treatment of orthopedic injuries or conditions. They may be used to replace lost tissue, stimulate regeneration and healing, reduce pain and inflammation and improve joint function. Orthobiologics are indicated for the treatment of articular cartilage injuries, osteoarthritis, ligament injuries, and tendon injuries. They may be administered in the form of injections or may require a surgical procedure. They may be used alone as conservative treatment, at the time of or following orthopedic surgery to enhance results. It is important for patients to know that there is a lot of misunderstanding as to the precise role that orthobiologics have in the treatment of musculoskeletal injury. Most likely, the growth factors and not the cells themselves will have an impact on inflammation and healing. It is unlikely, however, that orthobiologics will play a role in “regeneration” in any application in orthopeadics at this time although several investigations are ongoing.

OrthoBiologics Basics

The Use of OrthoBiologics in Clinical Practice

BMAC & PRP – General Information

Different types of orthobiologics include:

Platelet rich plasma (PRP): PRP is obtained from your own blood after it has been processed to concentrate platelets and certain white blood cells that enhance healing and reduce inflammation. PRP may be injected directly into the damaged tissue during an outpatient procedure, at the time of or following repair surgery.

Bone marrow aspiration concentrate (BMAC): BMAC is obtained after processing bone marrow that is removed from a bone region. BMAC is rich in stem cells, which produce proteins and growth factors necessary for healing and reducing inflammation.

Adipose tissue: Adipose tissue or fat cells have remarkable healing and regenerative properties. It is typically obtained from your waist, processed to remove impurities and inflammatory components, and then injected at the site of injury.

Dr. Cole’s related publications


The Use of OrthoBiologics in Clinical Practice

Orthobiologics as an Adjunct to Rotator Cuff Repair (2021)

Dr. Cole Lectures on the Use of Biologics to Improve Rotator Cuff Repair (2020)

Dr. Cole Lectures on The Use of MSCs to Treat Osteoarthritis (2020)

Biologic Association Summit 2020 – Platelet Rich Plasma

Clinical Application of Orthobiologics: RCR Augmentation

The Orthobiologic Institute Virtual Symposium: About the ON Foundation

Biologic Association Presentation: Clinical Application of Orthobiologics – Tendons

Biologic Association Presentation: The Business of PRP – In the Office & in the Operating Room

Biologic Association Presentation: Clinical Application of Orthobiologics – RCR Augmentation

Biologic Association Presentation: Platelet Rich Plasma

ON Foundation Case Presentation 2020: Osteochondral Defect of the Humeral Head

ON Foundation Live Q&A Series: Perspectives on Orthoregeneration with Dr. Brian Cole

Use of PRP for foot and ankle conditions at Rush

Use of PRP for lateral epicondylitis

Use of orthobiologics in spine surgery at Rush

Midwest Orthopaedic Surgeons at Rush educate patients on the proper indications and expectations related to the use of stem cell therapies and orthobiologics

Dr. Cole’s use of stem cells during rotator cuff repair

PRP for Treatment of Lateral Epicondylitis at Midwest Orthopedics

Use of orthobiologics and research at Rush

Regenerative Medicine Efforts at Rush

New Frontiers in Biologics

PRP and Research at Rush | Midwest Orthopaedics

Platelet Rich Plasma and Injection Technique

Stem Cells for the Treatment of Arthritis | Dr. Brian Cole

Bone Marrow Aspiration from 2017 Chicago Sports Medicine Symposium | Brian Cole MD, MBA